Open Period: 4/2/2025 – 9/9/2025

Orbital Edge Accelerator Program

Through the accelerator, six pioneering startups will be selected to receive an investment up to $500,000 each, mentorship, and the opportunity to launch an ISS National Lab-sponsored investigation.

Past Opportunity  

NASA astronaut Nick Hague with the CASIS PCG-14 investigation in the Destiny module of the ISS.

Open Period: 2/12/2025 – 6/2/2025

NLRA 2025-6: Leveraging the ISS National Lab for STEM Education and Workforce Development

The purpose of this NLRA is to solicit proposals for workforce development and STEM education using the unique resources of the ISS National Lab.

Past Opportunity  

Open Period: 1/7/2025 – 5/19/2025

NLRA 2025-5: Technology Advancement and Applied Research Leveraging the ISS National Lab,...

The purpose of this NLRA is to solicit proposals focused on flight investigations within applied R&D, translational medicine, technology readiness level maturation, and technology demonstration.

Past Opportunity  

The Ring Sheared Drop system containing concentrated solution of human serum albumin (the main protein constituent of blood).

Open Period: 1/3/2025 - 4/10/2025

NSF/CASIS 2025 Collaboration on Transport Phenomena Research on the ISS to Benefit Life on...

The purpose of this solicitation is to attract proposals that make use of the ISS National Lab for flight research projects in the field of transport phenomena.

Past Opportunity  

NASA astronaut Jasmin Moghbeli works with the BioFabrication Facility onboard the ISS

Open Period: 11/29/2024 - 3/18/2025

NSF/CASIS 2025 Collaboration on Tissue Engineering and Mechanobiology on the ISS to Benefit...

The purpose of this solicitation is to attract proposals that make use of the ISS National Lab for flight research projects in the field of biomedical engineering.

Past Opportunity  

NASA astronaut and Expedition 71 Flight Engineer Tracy C. Dyson cleans the inside of the Life Science Glovebox located aboard the International Space Station's Kibo laboratory. Dyson had earlier completed stem cell research operations exploring ways to advance cellular manufacturing and improve human health.

Open Period: Cancelled

NLRA 2025-1: ISS National Lab Research Announcement For Follow-On Projects

This NLRA seeks proposals focused on flight investigations within applied R&D, translational medicine, technology readiness level maturation, and technology demonstration.

Past Opportunity  

NASA astronaut Christina Koch works on the University of Washington kidney tissue chip investigation inside the Life Sciences Glovebox onboard the ISS.

Open Period: 7/25/2024 – 10/18/2024

Tissue Chips in Space 2.0: Translational Multi-Organ Tissue Chip Systems for Drug Efficacy,...

The purpose of this ISS National Lab Research Announcement is to solicit proposals for applied R&D to demonstrate space-based manufacturing and production activities in microgravity.

Past Opportunity  

NASA astronaut Peggy Whitson works on the Oncolinx investigation onboard the ISS.

Open Period: 7/10/2024 – 10/28/2024

Technology in Space Prize 2024 (Funded by Boeing and CASIS in Partnership with MassChallenge)

The prize is open to startups that participate in a MassChallenge program and provides an opportunity to utilize the ISS National Lab to conduct innovative research and technology development (R&D).

Past Opportunity  

The MISSE Flight Facility, a commercially available orbital research facility that resides externally onboard the ISS, offers researchers the ability to test concepts in the extreme environment of space.

Open Period: 5/14/2024 – 10/16/2024

NLRA 2024-7: Technology Advancement and Applied Research Leveraging the ISS National Lab

The purpose of this NLRA is to solicit proposals focused on flight investigations within applied R&D, translational medicine, technology readiness level maturation, and technology demonstration.

Past Opportunity  

NASA astronaut and Expedition 65 Flight Engineer Megan McArthur works in the Microgravity Science Glovebox on the ISS.

Open Period: 3/6/2024 – 7/15/2024

NLRA 2024-6: In-space Production Applications: Advanced Materials and Manufacturing

The purpose of this NLRA is to solicit proposals focused on flight investigations within applied R&D, translational medicine, technology readiness level maturation, and technology demonstrations.

Past Opportunity  

Space Station Ambassador and educator, Laura Tomlin participating in a reduced gravity flight as part of the Embedded Teachers Program

Open Period: 2/27/2024 – 7/1/2024

NLRA 2024-5 Leveraging the International Space Station for STEM Education and Workforce...

The purpose of this NLRA is to solicit proposals for applied research and development seeking to demonstrate space-based biomanufacturing activities in microgravity.

Past Opportunity  

ESA astronaut Alexander Gerst and NASA astronaut Reid Wiseman work in the Microgravity Science Glovebox onboard the ISS

Open Period: 1/9/2024 – 5/7/2024

NLRA 2024-4 Technology Advancement and Applied Research Leveraging the ISS National Lab

The purpose of this NLRA is to solicit proposals focused on flight investigations within applied R&D, translational medicine, technology readiness level maturation, and technology demonstration.

Past Opportunity